A large review of existing neuroscientific studies unravels the brain circuits and mechanisms that underpin obsessive-compulsive disorder. The researchers hope that the new findings will make existing therapies more effective, “or guide new treatments.”
Obsessive-compulsive disorder (OCD) is a mental health condition that affects more than 2 million adults in the United States.
People with OCD often experience recurring, anxiety-inducing thoughts or urges — known as obsessions — or compulsive behaviors that they cannot control.
Whether it is repeatedly checking if the door is locked or switching lights on and off, OCD symptoms are uncontrollable and can severely interfere with a person’s quality of life.
Treatments for OCD include medication, psychotherapy, and deep brain stimulation. However, not everyone responds to treatment.
In fact, reference studies have found that only 50 percent of people with OCD get better with treatment, and just 10 percent recover fully.
This treatment ineffectiveness is partly down to the fact that medical professionals still do not fully understand the neurological roots of the condition. A new study, however, aims to fill this gap in research.
Scientists led by Luke Norman, Ph.D., a postdoctoral research fellow in the Department of Psychiatry at the University of Michigan (U-M) in Ann Arbor, corroborated and analyzed large amounts of data from existing studies on the neurological underpinnings of OCD.
The scientists published their meta-analysis in the journal Biological Psychiatry.